|LC Classifications||QD453 .C76|
|The Physical Object|
|Pagination||xii, 211 p.|
|Number of Pages||211|
|LC Control Number||48014597|
(1) Rational Approach to Chemical Principles (2) The Elements of Physical Chemistry (3) Physical Chemistry (4) Physical Chemistry Skip to main content Thank you for visiting : J. A. V. Butler. Chemical Approaches to Rational Drug Design Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase, J.R. McCarthy and P.S. Sunkara. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors, A. Stern. Rational Approaches to Structure, Activity, and Ecotoxicology of Agrochemicals - CRC Press Book This book presents discussions of the most important aspects in the development of agrochemicals. The book covers such broad areas as structure activity and ecotoxicological analyses in comprehensive reviews for general methods and chronicles for. Introduction to Chemistry Principles, Eleventh Edition focuses on the most important topics — omitting organic and biochemistry chapters — and teaches the problem-solving skills readers need. Each topic is introduced and developed step by step until reaching the level of sophistication required for further course by:
Introduction to Chemistry Principles, Eleventh Edition focuses on the most important topics -- omitting organic and biochemistry chapters -- and teaches the problem-solving skills readers need. Each topic is Newly updated based on extensive reviewer feedback, this affordable introductory text remains focused on the essentials necessary for /5. Since the first synthesis of zeolites in s, these materials and related inorganic open-framework materials with regular nanoporous space have attracted considerable interest. Zeolites are important for catalysis, adsorption, and ion-exchange, and researchers are finding new applications for these materials in optics, electronics, sensors, and medicine. In particular, the petrochemical Cited by: More than 30 years ago, Earle H. Spaulding devised a rational approach to disinfection and sterilization of patient-care items and equipment. 14 This classification scheme is so clear and logical that it has been retained, refined, and successfully used by infection control professionals and others when planning methods for disinfection or. The discovery strategies from the historical ones to the most modern approaches are reviewed. They consist into mainly five approaches: the improvement of already existing drugs, the systematic screening, the exploitation of observed biological activities, the attempts towards rational design and the target protein structure-based approaches.
An historical context is given to the topic of drug discovery, followed by a high level overview of modern approaches to rational drug design. The approaches and steps typically encountered in modern rational drug design, including target identification, lead . D. Physiological Mechanisms: the Modern “Rational Approach” to Drug Design E: Approaches to Lead Optimization 1. Bioisosteric replacement 2. Conformation restriction a. Increase selectivity b. Increase affinity 3. Pharmacophore 4. Molecular dissection 5. Metabolic stabilization III. Rational decision making favors objective data and a formal process of analysis over subjectivity and intuition. The model of rational decision making assumes that the decision maker has full or perfect information about alternatives; it also assumes they have the time, cognitive ability, and resources to evaluate each choice against the others. ACS Chemical Biology , 14 (9), DOI: /acschembio.9b Hoi-Yun Jung, Sukbok Chang, Sungwoo Hong. Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C–H Amidation. Organic Letters , 21 (17), DOI: /t.9bCited by: